反应详情

温度

25 °C

Into the 200 ml jacketed reactor described in Example II were added 18.0 grams (0.152 m) alpha-methylstyrene, 18.4 grams (0.11 m) 87.6% 1,1,3,3-tetramethylbutyl hydroperoxide and 4.6 grams (0.048 m) phenol. The mixture was stirred to obtain a clear solution and the temperature was adjusted to 20° C. To this solution was added 1.7 grams (0.011 m) of t-cumyl chloride from the addition funnel over 5 minutes while holding the temperature at 20°-21° C. The reaction was stirred 5 minutes at 21°-22° C., warmed to 25° C. and stirred 1/2 hour at 25° C., 1/2 hour at 30° C., 1/2 hour at 35° C., 11/2 hours at 40° C. and finally 1/2 hour at 45° C. At this point the t-octyl hydroperoxide had been completely consumed and the reaction was terminated by adding 50 mls of water, stirring 5 minutes, adding 10 mls of 50% NaOH, stirring another 5 minutes and separating the aqueous caustic layer. The organic layer was successively washed with 50 mls 15% NaOH, saturated NaHCO3 solution, H2O, 15% NaHSO3 solution, saturated NaHCO3 solution and water. After drying over anhydrous sodium sulfate the crude product weighed 32.6 grams and contained 72.6% cumyl t-octyl peroxide for a corrected yield of 23.7 grams and a 81.5% yield.

1. customto obtain a clear solution
2. customwas adjusted to 20° C
3. customat 20°-21° C
4. stirringThe reaction was stirred 5 minutes at 21°-22° C.
5. stirringstirred 1/2 hour at 25° C., 1/2 hour at 30° C., 1/2 hour at 35° C.
6. custom2 hours
7. customat 40° C.
8. customfinally 1/2 hour
9. customat 45° C
10. customAt this point the t-octyl hydroperoxide had been completely consumed
11. customthe reaction was terminated
12. additionby adding 50 mls of water
13. stirringstirring 5 minutes
14. additionadding 10 mls of 50% NaOH
15. stirringstirring another 5 minutes
16. customseparating the aqueous caustic layer
17. washThe organic layer was successively washed with 50 mls 15% NaOH, saturated NaHCO3 solution, H2O, 15% NaHSO3 solution, saturated NaHCO3 solution and water
18. dry with materialAfter drying over anhydrous sodium sulfate the crude product