反应详情

2,5-dichlorobenzoic acid (5 g) and 3,5-diisopropylphenol (4.66 g) were dissolved in dry xylene and the solution placed under dry oxygen-free nitrogen. Sodium hydride (1.25 g) was added as a suspension in petroleum ether. Cuprous bromide was added and the solution refluxed for 5 hours and cooled. The xylene was removed by low pressure distillation. The remaining solid was acidified with dilute hydrochloric acid and extracted with diethyl ether. The ethereal layer was separated, dried and distilled under low pressure to give an oil. The oil was dissolved in petroleum ether (30°-40° ). Standing gave a crystalline solid, which was recrystallised from hexane to give the title compound (4.3 g), mp 129°-130° C.

1. temperaturethe solution refluxed for 5 hours
2. temperaturecooled
3. customThe xylene was removed by low pressure distillation
4. extractionextracted with diethyl ether
5. customThe ethereal layer was separated
6. customdried
7. distillationdistilled under low pressure
8. customto give an oil
9. customStanding gave a crystalline solid, which
10. customwas recrystallised from hexane