HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 13014004, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | L-Tyrosine | HCID 6057 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-Carbethoxyphthalimide | HCID 31187 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13014004 | HCID 13014004 | 49% |
Reaction Steps
O-Acetyl-N-phthaloyltyrosine (m.p. 176°-179° C., prepared in 81% yield by treating N-phthaloyltyrosine with acetic anhydride in pyridine; the N-phthaloyltyrosine being prepared in 91% yield from N-carbethoxyphthalimide, triethylamine and L-tyrosine in dimethyl sulphoxide in view of the poor solubility of L-tyrosine in water) is treated substantially by the procedure described in Example 1 (1) to give 4-(4-acetoxyphenyl)-3-phthalimidobutanoic acid in 49% yield, m.p. 151°-153.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04242256 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-0dcea4aae1934f12a5b0ea0861c57a3d |
| Source note | uspto-grants-1980_12 |