Hydrochloric Acid → 3-Chloro-8-(1-piperazinyl)imidazo[1,2-a]pyrazine

Participants

Reaction Steps

Employing the procedure substantially as described in Example 2, Step B, but substituting for the starting material used therein an equimolecular amount of each of 3,6-dichloroimidazo[1,2-a]pyrazine and 8-bromo-3,6-dichloroimidazo[1,2-a]pyrazine, there is produced respectively: 3-chloro-6-(1-piperazinyl)imidazo[1,2-a]pyrazine. HCl.1/2 H2O (m.p. >300° C.); and 3,6-dichloro-8-(1-piperazinyl)imidazo[1,2-a]pyrazine.HCl (m.p. >350° C.).

Provenance & Evidence