反应详情

The starting material is prepared as follows: The solution of 94.5 g of 1-benzyl-4-piperidone and 46 g of methoxyammonium chloride in 600 ml of ethanol-pyridine (1:1) is refluxed overnight and evaporated. The residue is dissolved in water, the solution made basic with 12.5% aqueous sodium hydroxide and extracted with diethyl ether. The extract is washed with water and saturated aqueous sodium hydroxide, dried and evaporated, to yield the 1-benzyl-4-methoxyiminopiperidine.

1. customThe starting material is prepared
2. customevaporated
3. dissolutionThe residue is dissolved in water
4. extractionextracted with diethyl ether
5. washThe extract is washed with water and saturated aqueous sodium hydroxide
6. customdried
7. customevaporated