Cyclohexaneacetic acid → HCID 20299756, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 20 g of 3-methoxy-benzeneethanamine and 15.2 g of cyclohexylacetic acid was heated at 190°-200° C. under an inert atmosphere for 45 minutes and was then cooled to 30° C. The product was dissolved in ethyl acetate and the solution was washed successively with N sodium hydroxide solution, N hydrochloric acid and water and was evaporated to dryness. The 29 g of oil residue was crystallized from petroleum ether (b.p.=40°-70° C.) and the product was dried to obtain 21.3 g of N-[2-(3-methoxyphenyl)-ethyl]cyclohexane-acetamide in the form of a white solid melting at 74° C.

Provenance & Evidence