Dichloromethane → HCID 178490147, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 5 g of the product of Step A, 2.5 g of lithium aluminum hydride and 50 ml of tetrahydrofuran was refluxed for 90 minutes and was then cooled to 10° C. 100 ml of tetrahydrofuran containing 20% water and 100 ml of methylene chloride were added thereto and the mixture was filtered. The filtrate was evaported to dryness and the 4.7 g of yellow oil residue were dissolved in 30 ml of isopropanol. A solution of ethyl acetate saturated with hydrogen chloride was added thereto to adjust the pH to 1 and the mixture was vacuum filtered. The recovered product was washed with isopropanol to obtain 3 g of N-[2-(3-methoxyphenyl)-ethyl]-1H-imidazol-4-ethanamine dihydroch1oride in the form of brilliant colorless platelets melting at 195°-198° C.

Provenance & Evidence