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4-tert-Butylbenzenesulfonamide → N-[4-(hexadecylamino)benzoyl]-4-t-butylbenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-tert-Butylbenzenesulfonamide | HCID 222872 | — |
| 反応物 | 4-Hexadecylaminobenzoyl chloride hydrochloride | HCID 13255322 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-[4-(hexadecylamino)benzoyl]-4-t-butylbenzenesulfonamide | HCID 20437349 | — |
反応手順
A solution of 21.1 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride and 10.8 g. of p-tert-butylbenzenesulfonamide in 250 ml. of pyridine was stirred under reflux for 2 hours and evaporated. The residue was partitioned between 1 N hydrochloric acid and CH2Cl2 and the organic layer was separated, washed with water, dried (MgSO4), and evaporated. Crystallization of the residual glass from CH2Cl2 hexane afforded a white solid, melting point 173°-176° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04242273 |
| 出典データセット | uspto-grants-1980_12 |
| ORD ID | ord-2f3bf2e68c5d454b99c234cab8010ca6 |
| 出典メモ | uspto-grants-1980_12 |