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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1733514Generated: October 25, 2026

Chloroform → 3-[4-(Hexadecylamino)benzoyl]-4-carboethoxythiazolidine

https://huagongshe.com/reaction/1733514

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChloroformHCID 6212—
ReactantTriethylamineHCID 8471—
ReactantEthyl thiazolidine-4-carboxylateHCID 103574—
Reactant4-Hexadecylaminobenzoyl chloride hydrochlorideHCID 13255322—
SolventDichloromethaneHCID 6344—
Product3-[4-(Hexadecylamino)benzoyl]-4-carboethoxythiazolidineHCID 20437342—

Reaction Steps

One-tenth mole of 4-(hexadecylamino)benzoyl chloride hydrochloride in methylene chloride is added to a solution of 0.1 mole of ethyl thiazolidine-4-carboxylate in chloroform containing two equivalents of triethylamine. After 5 hours at 20° C. the solution is filtered and evaporated to a white solid which is recrystallized from acetonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04242273
Source datasetuspto-grants-1980_12
ORD IDord-b438f0a10e6a44a6be7e4ba64147f148
Source noteuspto-grants-1980_12