反应详情

A solution of 10 g. of 4-(n-hexadecylamino)benzoic acid in 100 ml. dioxane is treated with 4.0 g. of t-butylazidoformate and 10 ml. pyridine. After stirring at room temperature for 18 hours, the protected amido-acid is precipitated from solution by addition of 150 ml. of water. The product is collected and thoroughly dried. The crude product is dissolved in 200 ml. of a mixture consisting of methylene chloride/dimethoxy ethane/pyridine (1:4:1), and to this is added 5.4 g. of 1,1'-carbonyldiimidazoye. The solution is stirred overnight at room temperature and the solvents are evaporated to yield the title compound as a thick, orange oil.

1. customthe protected amido-acid is precipitated from solution by addition of 150 ml
2. customThe product is collected
3. customthoroughly dried
4. dissolutionThe crude product is dissolved in 200 ml
5. additionto this is added 5.4 g
6. stirringThe solution is stirred overnight at room temperature
7. customthe solvents are evaporated