反应详情

A solution of 10 g. of 14-methylpentadecyl bromide and 10.8 g. of ethyl 4-aminobenzoate in 75 ml. hexamethylphosphoramide is heated at 120° C. for 17 hours. The cooled solution is diluted with 100 ml. water, filtered, and the residue is washed with 100 ml. 50% ethanol-water. The product is dried, then crystallized from ethanol to yield ethyl 4-(14-methylpentadecyl)aminobenzoate as colorless crystals.

1. additionThe cooled solution is diluted with 100 ml
2. filtrationwater, filtered
3. washthe residue is washed with 100 ml
4. customThe product is dried
5. customcrystallized from ethanol