Acetic Anhydride → HCID 20300066, compound

Participants

Reaction Steps

A mixture of 0.92 gram of 6-p-methoxy phenylimidazo[2,1-b]thiazole, 0.69 gram of (1-ethyl-2-methylindol-3-yl)(3-carboxypyridin-2-yl)ketone and 20 ml. of acetic anhydride was stirred 2.5 hours at 50° C. The reaction solution was poured into 250 ml. of water and adjusted to pH 9.8 with ammonium hydroxide. After one hour stirring the solid material was filtered and washed with water to give 1.44 grams (95%) of desired product, mp. 115°-118° C. The infrared spectrum showed a strong 1770 cm-1 lactone carbonyl peak. A solution of the product on silica gel produced a purple color.

Provenance & Evidence