Cyanoacetamide → 5-(2-Chlorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarbonitrile

Participants

Reaction Steps

In the manner described in Example 6, a solution of 48.6 g. of sodium methoxide and 42.0 g. of cyanoacetamide in 1000 ml. of methanol and 93.6 g. of 2-(2-chlorophenyl)-3-(dimethylamino)-2-propenal is refluxed for 16 hours to yield 30.0 g. of a tan solid. The solid is recrystallized from ethanol to yield the product of the Example as white needles, m.p. 252°-254° C.

Provenance & Evidence