反应详情

To a solution of 1.5 g. of sodium methoxide in 85 ml. of methanol is added 2.25 g. of dimethyl malonate and 2.93 g. of 3-amino-2-[3-(trifluoromethyl)phenyl]-2-propenal. The mixture is stirred at room temperature for 16 hours with precipitation of a yellow solid. The mixture is heated at reflux temperature for 2 hours, cooled and filtered to obtain a white solid. The solid is washed with ether, suspended in water and acidified with hydrochloric acid to yield 1.75 g. of the product of the Example as a white solid, m.p. 195°-201° C.

1. temperatureThe mixture is heated
2. temperatureat reflux temperature for 2 hours
3. temperaturecooled
4. filtrationfiltered
5. customto obtain a white solid
6. washThe solid is washed with ether
7. customto yield 1.75 g