Chloroform → HCID 20300182, compound

HRID 1733602Notes

Reaction equation

HRID 1733602 reaction equation
[OH:1][CH:2]1[CH:6]=[CH:5][S:4][CH:3]1[C:7]#[N:8].[CH:9](Cl)(Cl)Cl>[N+](=C)=[N-].CCOCC>[CH3:9][O:1][CH:2]1[CH:6]=[CH:5][S:4][CH:3]1[C:7]#[N:8]

Participants

5

Reactant 2

HCID 6212ChloroformHCID 20300174HCID 20300174, compound

Product 1

HCID 20300182HCID 20300182, compoundYield 72%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 9550DiazomethaneSolvent

Conditions

Temperature
0 °C

Procedure

12.7 parts of 3-hydroxy-2-cyanodihydrothiophene are dissolved in 100 parts by volume of chloroform and 200 parts by volume of a 4 percent strength by weight solution of diazomethane in ether are added at 0° C. The solution is stirred for 12 hours at 0° C. and is concentrated under reduced pressure. The residue is distilled. 10.1 parts (72% of theory) of 3-methoxy-2-cyanodihydrothiophene of boiling point 82°-83° C./0.35 mbar are obtained.

Workup

  1. additionare added at 0° C
  2. concentrationis concentrated under reduced pressure
  3. distillationThe residue is distilled

Sources & evidence

ORD record
ord-a8d4f826dccd4fafbbde5b4ba357377b
Source dataset
uspto-grants-1980_12
Patent number
US04242518

Reaction notes

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