Acetic Acid → Acetanilide

Participants

Reaction Steps

Acetic acid (0.3 g), triethylamine (0.7 ml) and aniline (0.5 g) are dissolved in ethyl acetate (10 ml), and thereto is added 1-methanesulfonyloxy-1,2,3-benzotriazole (1.05 g), and the mixture is stirred at room temperature for 1 hour. After allowing to stand overnight, the reaction mixture is extracted with ethyl acetate. The extract is washed with water and dried over anhydrous magnesium sulfate. After drying, the solvent is distilled off to give acetanilide (0.7 g). The product recrystallized from water has a melting point of 110°-112° C.

Provenance & Evidence