Ammonia → HCID 22808903, compound

Participants

Reaction Steps

N-Benzyloxycarbonyl-L-phenylalanine (1.5 g) and triethylamine (0.7 ml) are dissolved in anhydrous tetrahydrofuran (20 ml). To the solution is added 1-methanesulfonyloxy-1,2,3-benzotriazole (1.10 g) at room temperature and the mixture is stirred for 1 hour, and thereto is further added 28% aqueous ammonia (3.0 ml) and the mixture is stirred for 2 hours. After allowing to stand, the solvent is distilled off under a reduced pressure, and to the residue is added water and the crystals are crushed. The crystals are separated by filtration, washed with water and dried to give N-benzyloxycarbonyl-L-phenylalaninamide (1.15 g), melting point: 158°-160° C. The product is identified with an authentic sample by infrared spectrum.

Provenance & Evidence