Triethylamine → HCID 53791264, compound

Participants

Reaction Steps

N-Benzyloxycarbonyl-L-valine (1.25 g) and L-valine ethyl ester hydrochloride (1.08 g) are dissolved in dichloromethane (15 ml) and thereto are added triethylamine (1.54 ml) and further 1-methanesulfonyloxy-1,2,3-benzotriazole (1.07 g) under ice-cooling. After allowing to stand at room temperature for 72 hours, to the reaction mixture are added water and ethyl acetate. The ethyl acetate layer is separated, washed with water, dried and then the solvent is distilled off to give N-(N-benzyloxycarbonyl-L-valyl)-L-valine ethyl ester (1.70 g). The product is washed with petroleum ether to give powdery product (1.50 g), melting point: 93°-93.5° C.

Provenance & Evidence