Triethylamine → HCID 70591612, compound

Participants

Reaction Steps

N-Benzyloxycarbonyl-L-valine (1.26 g), glycine ethyl ester hydrochloride (0.70 g) and triethylamine (1.40 ml) are dissolved in anhydrous chloroform (10 ml), and thereto is added 1-methanesulfonyloxy-1,2,3-benzotriazole (1.05 g) with stirring under ice-cooling. After stirrig at room temperature for 20 hours, to the reaction mixture are added water and ethyl acetate. The ethyl acetate layer is separated, washed and dried. After drying, the solvent is distilled off to give N-(N-benzyloxycarbonyl-L-valyl)glycine ethyl ester hydrochloride (1.1 g), melting point: 162°-165° C.

Provenance & Evidence