Triethylamine → HCID 11337051, compound

Participants

Reaction Steps

N-Benzyloxycarbonyl-L-proline (1.25 g), L-serine methyl ester hydrochloride (0.78 g) and triethylamine (1.40 ml) are dissolved in dry chloroform (20 ml) and thereto is added 1-(p-chlorobenzenesulfonyloxy)-6-chloro-1,2,3-benzotriazole (1.72 g) under ice-cooling. After allowing to stand overnight, to the mixture are added water and ethyl acetate. The ethyl acetate layer is washed and dried, and then the solvent is distilled off to give N-(N-benzyloxycarbonyl-L-prolyl)-L-serine methyl ester (1.4 g), melting point: 96°-100° C.

Provenance & Evidence