Water → HCID 53852973, compound

Participants

Reaction Steps

N-Benzyloxycarbonyl-L-phenylalanine (1.5 g) and triethylamine (0.7 ml) are dissolved in ethyl acetate (15 ml). To the solution is added 1-methanesulfonyloxy-1,2,3-benzotriazole (1.1 g) under ice-cooling and the mixture is stirred for 1 hour. After allowing to stand overnight, to the reaction mixture are added ethyl acetate and water. The ethyl acetate layer is separated, washed with water and dried over anhydrous magnesium sulfate. After drying, the solvent is distilled off and to the residue is added ether. The precipitated crystals are separated by filtration to give 1-(N-benzyloxycarbonyl-L-phenylalanyloxy)-1,2,3-benzotriazole (1.3 g), melting point: 120°-125° C.

Provenance & Evidence