Methanol → Methyl heptanoate

Participants

Reaction Steps

Heptanoic acid (1.30 g) is dissolved in chloroform (15 ml) and thereto are added triethylamine under ice-cooling and further 1-(p-chlorobenzenesulfonyloxy)-6-chloro-1,2,3-benzotriazole (3.44 g), and the mixture is stirred for 3 hours. To the solution are added methanol (0.61 ml) and triethylamine (1.40 ml), whereby exothermic reaction occurs. After stirring for 10 minutes, chloroform is distilled off and to the resulting residue are added water and ether. The ether layer is washed with water, an aqueous sodium hydrogen carbonate and water in order, dried over anhydrous magnesium sulfate and the solvent is distilled off to give methyl heptanoate (1.25 g).

Provenance & Evidence