Triethylamine → HCID 12274051, compound

Participants

Reaction Steps

N-Hydroxysuccinimide (11.5 g) and triethylamine (14.0 ml) are suspended into a mixture of benzene (100 ml) and dioxane (50 ml), and thereto is added dropwise a solution of methanesulfonyl chloride (7.8 ml) in benzene (20 ml) with stirring under ice-cooling and the mixture is stirred for 1 hour. After allowing to stand overnight, the solvent is distilled off. To the residue is added water and the resulting crystals are separated by filtration, washed with water and dried to give N-methanesulfonyloxysuccinimide (6.3 g), melting point: 148°-150° C. The product is recrystallized from ethyl acetate-petroleum ether to give crystals having a melting point of 150°-152° C.

Provenance & Evidence