7-Amino-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3cephem-4-carboxylic acid → HCID 131712004, compound

HRID 1733737Notes

Reaction equation

HRID 1733737 reaction equation
[O:1]=[C:2]1[S:6][C:5]([C:7](=[N:11][O:12][CH3:13])[C:8]([OH:10])=O)=[CH:4][S:3]1.[NH2:14][CH:15]1[C:32](=[O:33])[N:17]2[C:18]([C:29]([OH:31])=[O:30])=[C:19]([CH2:22][S:23][C:24]3[S:25][CH:26]=[N:27][N:28]=3)[CH2:20][S:21][C@H:16]12>>[O:1]=[C:2]1[S:6][C:5]([C:7](=[N:11][O:12][CH3:13])[C:8]([NH:14][CH:15]2[C:32](=[O:33])[N:17]3[C:18]([C:29]([OH:31])=[O:30])=[C:19]([CH2:22][S:23][C:24]4[S:25][CH:26]=[N:27][N:28]=4)[CH2:20][S:21][C@H:16]23)=[O:10])=[CH:4][S:3]1

Participants

3

Reactant 2

HCID 128891877-Amino-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3cephem-4-carboxylic acidHCID 57010139HCID 57010139, compound

Product 1

HCID 131712004HCID 131712004, compound

Procedure

2-(2-Oxo-1,3-dithiol-4-yl)-2-methoxyiminoacetic acid (anti isomer, 0.7 g.) was allowed to react with 7-amino-3-(1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid (1.06 g.) in a similar manner to that of Example 1 to give the captioned compound (0.85 g.).

Workup

  1. customto give the captioned compound (0.85 g.)

Sources & evidence

ORD record
ord-cae56c9bf3c84d579e9e9c9adb8f19ab
Source dataset
uspto-grants-1980_12
Patent number
US04242510

Reaction notes

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