Triethyl phosphite → Diethyl 3-trifluoromethylbenzylphosphonate

Participants

Reaction Steps

A mixture of 3-trifluoromethylbenzyl bromide (5.74 g, 24.0 mmol) and triethyl phosphite (4.98 g, 30 mmol) was heated at reflux under nitrogen for 3 hours. The excess triethyl phosphite was removed by distillation and the crude product obtained was distilled at 140°-145° C. at 4 mm to yield 6.44 g (90.7%) of analytically pure product as a clear liquid. 300 MHz 1H NMR (CDCl3): δ, 3.20 (d,2H J=21.78 Hz, PCH2). D.C.I.M.S.[MH+, 297].

Provenance & Evidence