Triethyl phosphite → Diethyl {[3,5-bis(trifluoromethyl)phenyl]methyl}phosphonate

Participants

Reaction Conditions

Reaction Steps

A mixture of 3,5-bis-trifluoromethylbenzyl bromide (5.0 g, 16 mmol) and triethyl phosphite (3.4 g, 20 mmol) was heated at 160° C. for 20 hours. The reaction mixture was cooled and distilled at 83° C. (0.03 mm Hg) to give 2.36 g of the product as a colorless oil in 48% yield. D.C.I.M.S. [MH+, 365].

Provenance & Evidence