Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Nitrophenyl)-1H-imidazole | HCID 123155 | — |
Reaction Steps
To a solution of 4-fluoronitrobenzene (25 g; ~0.18 mol) in 250 ml N,N-dimethylformamide was added imidazole (50 g; ~0.74 mol). The reaction mixture was stirred at 140° C. for 2 h, and then poured into ice-water to give the title compound as a precipitate. Yield: 32 g (~94%). M.p. 199°-202° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05532236 |
|---|
| Source dataset | uspto-grants-1996_07 |
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| ORD ID | ord-45443d89398649b59c696792a43a0d55 |
|---|
| Source note | uspto-grants-1996_07 |
|---|
