Hydrazinecarboxylic acid, ethyl ester → HCID 19438800, compound

HRID 1733874Notes

Reaction equation

HRID 1733874 reaction equation
[CH2:1]([O:8][N:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([N:19]3[CH:23]=[CH:22][N:21]=[CH:20]3)[CH:17]=2)[N:12]=[C:11](Cl)[C:10]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:26]([O:30][CH2:31][CH3:32])(=[O:29])[NH:27][NH2:28]>C(#N)C>[CH2:1]([O:8][N:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([N:19]3[CH:23]=[CH:22][N:21]=[CH:20]3)[CH:17]=2)[N:12]=[C:11]([NH:28][NH:27][C:26]([O:30][CH2:31][CH3:32])=[O:29])[C:10]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 19438789HCID 19438789, compound

Product 1

HCID 19438800HCID 19438800, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 4-benzyloxy-2-chloro-6-(1H-imidazol-1-yl)-quinoxalin-3(4H)-one (9.4 g; ~27.6 mmol) in 500 ml acetonitrile was added ethyl carbazate (28 g; ~270 mmol). The reaction mixture was refluxed overnight. Cooling to room temperature gave the title compound (11.1 g; 99%) as a precipitate. M.p. 197°-199° C.

Workup

  1. temperatureThe reaction mixture was refluxed overnight

Sources & evidence

ORD record
ord-d9369e44877e46d5b440dbd877dd66fa
Source dataset
uspto-grants-1996_07
Patent number
US05532236

Reaction notes

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