HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 19438759, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Methylimidazole | HCID 12749 | — |
| Reactant | 5-Chloro-2-nitro-4-(trifluoromethyl)aniline | HCID 2773813 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19438759 | HCID 19438759 | 62% |
Reaction Steps
To a solution of 20.0 g (~83 mmol) 4-amino-2-chloro-5-nitrobenzotrifluoride in 50 ml dry N,N-dimethylformamide was added 30 g (~370 mmol) 2-methylimidazole, and stirring was continued at 180° C. for 30 h. The reaction mixture was poured into 400 ml water to give the title compound (14.7 g; 62%). M.p. 222°-225° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05532236 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-e1f11fc8ab4d4bdeaafbc16ddcd36213 |
| Source note | uspto-grants-1996_07 |