Ammonium Hydroxide → 4-Amino-2-fluoro-5-nitrobenzonitrile

Participants

Reaction Steps

20 g (108 mmol) of 2,4-difluoro-5-nitrobenzonitrile was added to 200 ml of 25% ammonium hydroxide and the mixture was stirred for 90 min. at room temperature. The yellow precipitate was isolated by filtration and washed with water and a small amount of cold ethanol to give 18.8 g (96%) of the title compound. M.p. 197°-199° C.

Provenance & Evidence