Toluene → HCID 19438761, compound

Participants

Reaction Steps

A solution of 20% phosgene in toluene (50 ml, 96 mmol) was added dropwise to a stirred solution of 12.1 g (30 mmol) of 1-benzyl-6-(1H-imidazol-1-yl)-7-trifluoromethylquinoxaline-2,3(1H,4H)-dione in 100 ml of dry N,N-dimethylformamide at room temperature. The mixture was stirred at room temperature overnight and neutralized by cautious addition of 16 g (190 mmol) of sodium hydrogen carbonate. After 10 min. the mixture was poured into 500 ml of water. Light petroleum (200 ml) was added under vigorous stirring and the solid formed was isolated by filtration. The product was washed with water and ether and dried in vacuo to give 11.0 g (87%) of crude title compound.

Provenance & Evidence