Hydrochloric Acid → HCID 131719443, compound

Participants

Reaction Steps

Cis-2, 6-Dibenzyl-6-hydroxydecahydroisoquinoline (Example 42, 300 mg) was dissolved in ethanol (10 mL). A saturated solution of hydrogen chloride in ether (3 mL) was added with stirring. The mixture was concentrated in vacuo. The residue was triturated with copious amounts of diethyl ether and filtered. Drying in vacuo at 60° C. afforded a white solid (240 mg): mp 232° C.; Anal. Calcd for C23H29NO.HCl: C, 74.27, H, 8.13, N, 3.77, C1, 9.53, Found: C, 74.10, H, 8.22, N, 3.38, Cl, 9.40.

Provenance & Evidence