HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methoxytryptamine → 1-[2-(5-Methoxyindol-3-yl)ethyl]-4-(chroman-6-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methoxytryptamine | HCID 1833 | — |
| Reactant | 6-[N,N-bis(2-chloroethyl)amino]chroman | HCID 19438878 | — |
| Product | 1-[2-(5-Methoxyindol-3-yl)ethyl]-4-(chroman-6-yl)piperazine | HCID 19438866 | — |
Reaction Steps
Analogously to Example 5, reaction of 3.2 g of 3-(2-aminoethyl)-5-methoxyindole with 1.3 equivalents of 6-[N,N-bis(2-chloroethyl)amino]chroman [obtainable by reaction of 2-chloroacetyl chloride with 6-aminochroman and subsequent reduction with diborane] gives 1-[2-(5-methoxyindol-3-yl)ethyl]-4-(chroman-6-yl)piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05532241 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-b588d417fcf641ceaa51e12a840033b0 |
| Source note | uspto-grants-1996_07 |