2-Bromoacetamide → 9-(4-Pyridinylmethyl)-9H-fluoren-9-acetamide Hemihydrate

HRID 1733922Notes

Reaction equation

HRID 1733922 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH:8]2[C:20]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:14]3[C:9]2=[CH:10][CH:11]=[CH:12][CH:13]=3)=[CH:3][CH:2]=1.Br[CH2:22][C:23]([NH2:25])=[O:24]>>[OH2:24].[N:1]1[CH:2]=[CH:3][C:4]([CH2:7][C:8]2([CH2:22][C:23]([NH2:25])=[O:24])[C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[C:15]3[C:20]2=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:5][CH:6]=1.[N:1]1[CH:2]=[CH:3][C:4]([CH2:7][C:8]2([CH2:22][C:23]([NH2:25])=[O:24])[C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=3[C:15]3[C:20]2=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 696322-BromoacetamideHCID 158379559-(4-pyridinylmethyl)-9H-fluorene

Product 1

HCID 702802089-(4-Pyridinylmethyl)-9H-fluoren-9-acetamide HemihydrateYield 45%

Procedure

By substituting 9-(4-pyridinylmethyl)-9H-fluorene and α-bromoacetamide in Ex. 1, the desired product was isolated in 45% yield; mp 156°-158° C.

Sources & evidence

ORD record
ord-be2f792c8f6a4436a2b9e3cea410de1c
Source dataset
uspto-grants-1996_07
Patent number
US05532249

Reaction notes

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