Sodium Hydroxide → HCID 19439068, compound

HRID 1733934Notes

Reaction equation

HRID 1733934 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH:13]([CH2:15][N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][C:24]([O:26]CC)=[O:25])[CH2:18][CH2:17]3)[O:12][C:11]2=[O:29])=[CH:6][CH:5]=1)(=[NH:3])[NH2:2].[OH-].[Na+].O1CCOCC1>O>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:14][CH:13]([CH2:15][N:16]3[CH2:17][CH2:18][N:19]([CH2:22][CH2:23][C:24]([OH:26])=[O:25])[CH2:20][CH2:21]3)[O:12][C:11]2=[O:29])=[CH:8][CH:9]=1)(=[NH:2])[NH2:3]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 19439141HCID 19439141, compound

Product 1

HCID 19439068HCID 19439068, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1 g of ethyl 3-(4-(3-(4-amidinophenyl)-2-oxo-5-oxazolidinylmethyl)-1-piperazinyl)propionate, 0.2 g of NaOH, 8 ml of dioxane and 2 ml of water is stirred at 20° for 5 hours. After acidification and conventional work-up, 3-(4-(3-(4-amidinophenyl)-2-oxo-5oxazolidinylmethyl)-1-piperazinyl)propionic acid m.p. 269°, is obtained

Sources & evidence

ORD record
ord-335684ee34fb41aaa46ab9e048fd3860
Source dataset
uspto-grants-1996_07
Patent number
US05532255

Reaction notes

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