Stannous Chloride → HCID 19699078, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.8 g of 6-(2-chloro-4-nitrobenzoyl)-1,4,5,6-tetrahydropyrazolo[3,4-d]thieno[3,2-b]azepine in 35 ml of absolute ethanol is added 5.42 g of tin (II) chloride followed by heating at reflux for 1 hour at 80° C. The volatiles are evaporated in vacuo to a residue which is partitioned between 150 ml of ethyl acetate and saturated aqueous NaHCO3 the reactants are stirred at room temperature for 1 hour and filtered. The organic layer is separated and washed with 30 ml of brine, dried (Na2SO4) and filtered through a pad of hydrous magnesium silicate. The filtrate is evaporated in vacuo to give 1.55 g of a yellow-orange foam.

Provenance & Evidence