Water → HCID 10519066, compound

Participants

Reaction Steps

A mixture of 0.5 g of 5-(4-nitrobenzoyl)-9-hydroxy-6,7,8,9-tetrahydro-5H-pyrido[3,2-b]azepine in 5 ml of dimethyl sulfoxide and 1 ml of acetic anhydride is stirred at room temperature 16 hours. To the mixture is added 10 ml of water and 1N NaHCO3. The mixture is extracted with ethyl acetate and the extract washed with water, 1N NaHCO3, brine and dried. The solvent is removed to give a solid. chromatography on silica gel with ethyl acetate as solvent gives the product as a solid, m.p. 188°-190° C.

Provenance & Evidence