HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1734009Generated: October 26, 2026
Ethylene Glycol → 3-(2-Methyl-1,3-dioxolan-2-yl)benzonitrile
https://huagongshe.com/reaction/1734009
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | 3-Acetylbenzonitrile | HCID 80222 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 3-(2-Methyl-1,3-dioxolan-2-yl)benzonitrile | HCID 10559546 | 99.7% |
Reaction Steps
A suspension of 3-acetylbenzonitrile (50.0 g), ethylene glycol (34.0 g) and boron trifluoride etherate (1 ml) in benzene (200 ml) was heated at 100° C. by means of a Dean-Stark apparatus for 5 hours. After cooling, a saturated aqueous sodium hydrogencarbonate solution (200 ml) was added. The benzene layer was collected and then dried with sodium sulfate. The solvent was removed under reduced pressure to afford 3-(2-methyl-1,3-dioxolan-2-yl)benzonitrile (65.0 g) (oil).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05532258 |
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| Source dataset | uspto-grants-1996_07 |
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| ORD ID | ord-5083d86795b24b1581068d6435b3d646 |
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| Source note | uspto-grants-1996_07 |
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