Chloroacetyl chloride → HCID 19439696, compound

Participants

Reaction Steps

Chloroacetyl chloride (17 g) was added dropwise to a mixture of aluminum chloride (13.3 g) in dichloroethane (60 ml) at ambient temperature under stirring and the mixture was stirred for one hour. To the resulting mixture was added N-(2-methylbenzyl)acetamide (13.3 g) at ambient temperature and the mixture was stirred at 25° to 50° C. for 1.5 hours. The reaction mixture was poured into ice water and extracted with a mixture of ethyl acetate and tetrahydrofuran. The extract was washed with brine and dried over magnesium sulfate. The solvent was concentrated in vacuo and the residue was washed with ethyl acetate and diisopropyl ether to give N-(4-chloroacetyl-2-methylbenzyl)acetamide (5.8 g).

Provenance & Evidence