1-[3-(Chloromethyl)-4-methoxyphenyl]ethan-1-one → HCID 3922617, compound

Participants

Reaction Steps

A solution of 3'-chloromethyl-4'-methoxyacetophenone (10.0 g) in N,N-dimethylformamide (30 ml) was added slowly to a suspension of potassium phthalimide (9.4 g) in N,N-dimethylformamide (70 ml) at room temperature and then the mixture was stirred for 9 hours at room temperature. After removed of the insoluble material, the solvent was removed under reduced pressure. The residue was suspended in water (100 ml). The mixture was extracted with ethyl acetate (300 ml). The extract was dried with magnesium sulfate. The solvent was removed under reduced pressure to afford 3'-phthalimidomethyl-4'-methoxyacetophenone (11.94 g).

Provenance & Evidence