Methylamine → HCID 178485036, compound

Participants

Reaction Steps

A solution of 4-(3-aminomethyl-4-methoxyphenyl)-2(diaminomethyleneamino)thiazole (350 mg) and N-[di(methylthio)methylene]cyanamide (190 mg) in N,N-dimethylformamide (20 ml) was heated at 70° C. for 2.5 hours. After cooling, 40% methylamine solution (6 ml) was added to the mixture and the mixture was stirred for 5 hours at room temperature. The solvent was removed under reduced pressure and the residue was chromatographed on a silica gel column eluting with a mixture of chloroform and methanol (10:1). Recrystallization from a mixture of methanol and diisopropyl ether afforded 2-(diamino-methyleneamino)-4-[3-{(3-methyl-2-cyanoguanidino)methyl}-4-methoxyphenyl]thiazole (180 mg).

Provenance & Evidence