1,4-Dioxane hydrochloride → HCID 178495978, compound

Participants

Reaction Steps

A solution of 2-[[(amino)(2-methoxyethylamino)methylene]amino]-4-(3-t-butoxycarbonylaminoacetylaminomethylphenyl)thiazole (1.6 g) and 4N-hydrogen chloride/dioxane (10 ml) in methanol (10 ml) was stirred at room temperature for 2.5 hours. The resulting precipitate was collected by filtration and then dissolved in water (50 ml). The mixture was alkalized to pH 10 with a 30% aqueous potassium carbonate solution. The resulting precipitate was collected by filtration. Recrystallization from a mixture of methanol and diisopropyl ether afforded 2-[[(amino)(2-methoxyethylamino)methylene]amino]-4-(3-aminoacetylaminomethylphenyl)thiazole (0.8 g).

Provenance & Evidence