1,4-Dioxane hydrochloride → HCID 178495977, compound

HRID 1734030Notes

Reaction equation

HRID 1734030 reaction equation
[ClH:1].O1CCOCC1.[C:8]([NH:11][CH2:12][C:13]1[CH:14]=[C:15]([C:19]2[N:20]=[C:21]([N:24]=[C:25]([NH2:31])[NH:26][CH2:27][CH2:28][O:29][CH3:30])[S:22][CH:23]=2)[CH:16]=[CH:17][CH:18]=1)(=[O:10])[CH3:9]>CO>[ClH:1].[C:8]([NH:11][CH2:12][C:13]1[CH:14]=[C:15]([C:19]2[N:20]=[C:21]([N:24]=[C:25]([NH2:31])[NH:26][CH2:27][CH2:28][O:29][CH3:30])[S:22][CH:23]=2)[CH:16]=[CH:17][CH:18]=1)(=[O:10])[CH3:9]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178495976HCID 178495976, compound

Product 1

HCID 178495977HCID 178495977, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4N-Hydrogen chloride/dioxane (10 ml) was added to a suspension of 4-(3-acetylaminomethylphenyl)-2-[[(amino)(2-methoxyethylamino)methylene]amino]thiazole (2.0 g) in methanol (20 ml). The mixture was stirred for 3 hours at room temperature. The resulting precipitate was collected by filtration. Recrystallization from water afforded 4-(3-acetylaminomethylphenyl)-2-[[(amino)(2-methoxyethylamino)methylene]amino]thiazole hydrochloride (0.9 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. customRecrystallization from water

Sources & evidence

ORD record
ord-6cdc2424be9f4a199b39bd0f97bbaec9
Source dataset
uspto-grants-1996_07
Patent number
US05532258

Reaction notes

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