Oxalate → HCID 21472054, compound

HRID 1734047Notes

Reaction equation

Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[C:15]2[CH2:14][CH2:13][NH:12][CH2:11][C:10]=2[S:9][C:8]=1[CH2:16][CH3:17])=[O:6].Cl.[F:19][C:20]1[CH:34]=[CH:33][C:23]2[C:24]([CH:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)=[N:25][O:26][C:22]=2[CH:21]=1.[C:35]([O-])(=O)[C:36]([O-])=[O:37]>>[C:36]([N:12]1[CH2:13][CH2:14][C:15]2[C:7]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][N:30]3[CH2:29][CH2:28][CH:27]([C:24]4[C:23]5[CH:33]=[CH:34][C:20]([F:19])=[CH:21][C:22]=5[O:26][N:25]=4)[CH2:32][CH2:31]3)=[C:8]([CH2:16][CH3:17])[S:9][C:10]=2[CH2:11]1)(=[O:37])[CH3:35]

Participants

Reactant 3

HCID 71081Oxalate

HCID 11334359R-56109 hydrochloride

HCID 86749601HCID 86749601, compound

Product 1

HCID 21472054HCID 21472054, compound

Procedure

The reaction and procedure were conducted in a similar manner as in Example 24 using 1.5 g of 6-acetyl-3-(4-chlorobutyryl-4,5,6,7-tetrahydro-2-ethylthieno[2,3-c]pyridine and 1.2 g of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 0.7 g of 6-acetyl-3-(4-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)butyryl)-4,5,6,7-tetrahydro-2-ethylthieno[2,3-c]pyridine as an oil, m.p. 93°-95° C. as oxalate 1/4 hydrate thereof.

Workup

customThe reaction and procedure

Sources & evidence

ORD record: ord-bd3bc9f1ab974b90890f89328d9c6742
Source dataset: uspto-grants-1996_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05532240

Reaction notes

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