R-56109 hydrochloride → HCID 21472072, compound

HRID 1734057Notes

Reaction equation

HRID 1734057 reaction equation
[C:1]([C:4]1[C:12]2[CH2:11][CH2:10][N:9]([C:13](=[O:15])[CH3:14])[CH2:8][C:7]=2[S:6][C:5]=1[CH2:16][CH2:17]Cl)(=[O:3])[CH3:2].Cl.[F:20][C:21]1[CH:35]=[CH:34][C:24]2[C:25]([CH:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)=[N:26][O:27][C:23]=2[CH:22]=1>>[C:1]([C:4]1[C:12]2[CH2:11][CH2:10][N:9]([C:13](=[O:15])[CH3:14])[CH2:8][C:7]=2[S:6][C:5]=1[CH2:16][CH2:17][N:31]1[CH2:30][CH2:29][CH:28]([C:25]2[C:24]3[CH:34]=[CH:35][C:21]([F:20])=[CH:22][C:23]=3[O:27][N:26]=2)[CH2:33][CH2:32]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 11334359R-56109 hydrochlorideHCID 21472085HCID 21472085, compound

Product 1

HCID 21472072HCID 21472072, compound

Procedure

The reaction and procedure were conducted in a similar manner as in Example 24 using 1.5 g of 3,6-diacetyl-2-(2-chloroethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine and 1.3 g of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 3,6-diacetyl-2-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine as an oil.

Workup

  1. customThe reaction and procedure

Sources & evidence

ORD record
ord-75349d4974134882878b416be19ada2c
Source dataset
uspto-grants-1996_07
Patent number
US05532240

Reaction notes

Loading…