R-56109 hydrochloride → HCID 21471954, compound

HRID 1734074Notes

Reaction equation

HRID 1734074 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[S:10][C:11]([CH3:19])=[C:12]([C:13](=[O:18])[CH2:14][CH2:15][CH2:16]Cl)[C:6]=2[CH2:5]1)(=[O:3])[CH3:2].Cl.[F:21][C:22]1[CH:36]=[CH:35][C:25]2[C:26]([CH:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)=[N:27][O:28][C:24]=2[CH:23]=1.O.C(O)(=O)C(O)=O>>[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[S:10][C:11]([CH3:19])=[C:12]([C:13](=[O:18])[CH2:14][CH2:15][CH2:16][N:32]3[CH2:31][CH2:30][CH:29]([C:26]4[C:25]5[CH:35]=[CH:36][C:22]([F:21])=[CH:23][C:24]=5[O:28][N:27]=4)[CH2:34][CH2:33]3)[C:6]=2[CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 11334359R-56109 hydrochlorideHCID 122529616153-56-6HCID 21472041HCID 21472041, compound

Product 1

HCID 21471954HCID 21471954, compoundYield 23.2%

Procedure

The reaction and procedure were conducted in a similar manner as in Example 24 using 1.6 g of 5-acetyl-3-(4-chlorobutyryl)-4,5,6,7-tetrahydro-2-methylthieno[3,2-c]pyridine and 1.4 g of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 0.6 g of 5-acetyl-3-(4-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)butyryl)-4,5,6,7-tetrahydro-2-methylthieno[3,2-c]pyridine as an oil, m.p. 116°-118° C. as an oxalate monohydrate thereof.

Workup

  1. customThe reaction and procedure

Sources & evidence

ORD record
ord-aae05b12aa40494697bf1fe4f1f6fdd4
Source dataset
uspto-grants-1996_07
Patent number
US05532240

Reaction notes

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