Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(1-Piperazinyl)-1,2-benzisothiazole → 6-Acetyl-3-(2-(4-(1,2-benzisothiazol-3-yl)piperazin-1-yl)ethyl)-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(1-Piperazinyl)-1,2-benzisothiazole | HCID 2772144 | — |
| 반응물 | 6-Acetyl-3-(2-chloroethyl)-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine | HCID 21471856 | — |
| 반응물 | 7-(4-(4-(1,2-benzisothiazol-3-yl) piperazin-1-yl)butyryl)-2,3-dihydrothieno[3,2-f][1,4]thiazepin-5(4H)-one oxalate | HCID 67744150 | — |
| 생성물 | 6-Acetyl-3-(2-(4-(1,2-benzisothiazol-3-yl)piperazin-1-yl)ethyl)-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine | HCID 21472044 | 58.5% |
반응 단계
The reaction and procedure were conducted in a similar manner as in Example 14 using 1.0 g of 6-acetyl-3-(2-chloroethyl)-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine and 0.88 g of 1-(1,2-benzoisothiazol- 3-yl)piperazine to give 1.0 g of 6-acetyl-3-(2-(4-(1,2-benzisothiazol-3-yl)piperazin-1-yl)ethyl)-4,5,6,7-tetrahydro-2-methylthieno[2,3-c]pyridine as an oil, m.p. 190°-192° C. (decomposition) as an oxalate 1/2 hydrate thereof.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05532240 |
| 출처 데이터셋 | uspto-grants-1996_07 |
| ORD ID | ord-79684cff66ec44e4b08f001d651bdcdf |
| 출처 메모 | uspto-grants-1996_07 |