Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
R-56109 hydrochloride → 6-Acetyl-2-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-3-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | R-56109 hydrochloride | HCID 11334359 | — |
| 반응물 | 6-Acetyl-2-(2-chloroethyl)-3-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine | HCID 21472043 | — |
| 반응물 | Dihydrate;hydrochloride | HCID 21899424 | — |
| 생성물 | 6-Acetyl-2-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-3-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine | HCID 21471922 | 42.6% |
반응 단계
The reaction and procedure were conducted in a similar manner as in Example 24 using 0.7 g of 6-acetyl-2-(2-chloroethyl)-3-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine and 0.67 g of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 0.5 g of 6-acetyl-2-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-3-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine as an oil, m.p. 165°-167° C. (decomposition) as hydrochloride dihydrate thereof.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05532240 |
| 출처 데이터셋 | uspto-grants-1996_07 |
| ORD ID | ord-fd6343f6aa444858b5f70da518fbdada |
| 출처 메모 | uspto-grants-1996_07 |