Oxalate → HCID 21471992, compound

HRID 1734083Notes

Reaction equation

HRID 1734083 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[C:10]([Br:16])=[C:11]([CH2:13][CH2:14]Cl)[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2].Cl.[F:18][C:19]1[CH:33]=[CH:32][C:22]2[C:23]([CH:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)=[N:24][O:25][C:21]=2[CH:20]=1.C([O-])(=O)C([O-])=O>>[C:1]([N:4]1[CH2:9][CH2:8][C:7]2[C:10]([Br:16])=[C:11]([CH2:13][CH2:14][N:29]3[CH2:28][CH2:27][CH:26]([C:23]4[C:22]5[CH:32]=[CH:33][C:19]([F:18])=[CH:20][C:21]=5[O:25][N:24]=4)[CH2:31][CH2:30]3)[S:12][C:6]=2[CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 71081OxalateHCID 11334359R-56109 hydrochlorideHCID 21471931HCID 21471931, compound

Product 1

HCID 21471992HCID 21471992, compoundYield 6.4%

Procedure

The reaction and procedure were conducted in a similar manner as in Example 24 using 0.5 g of 6-acetyl-3-bromo-2-(2-chloroethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine and 0.4 g of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 0.05 g of 6-acetyl-3-bromo-2-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine as an oil, m.p. 114°-117° C. as an oxalate thereof.

Workup

  1. customThe reaction and procedure

Sources & evidence

ORD record
ord-8db59394fc604282b4560de21f9b7f98
Source dataset
uspto-grants-1996_07
Patent number
US05532240

Reaction notes

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