Dimethylformamide → HCID 19439815, compound

Participants

Reaction Steps

A solution of 6-bromo-β-carboline (1.0 g, 4.05 mmol) in 12 mL of DMF was stirred in an ice bath and 186 mg (4.65 mmol, 1.15 equiv.) of 60% sodium hydride in mineral oil dispersion was added. Gas evolution was observed and stirring was continued for 1 h at ambient temperature. The homogenous reaction was partitioned between EtOAc and H2O. The organic layer was washed again with H2O followed by brine. After drying (MgSO4), evaporation gave a pale yellow solid.

Provenance & Evidence